Many patients who have migraine will experience their attacks during the middle of the night or early morning hours. This headache often awakens the patient from sleep. This type of migraine is often called nocturnal migraine.

Recent evidence suggests that these attacks are related to changes in neurotransmitters in the brain during sleep. It is recommended that patients treat the headache when the attack begins, elevate their upper torso (back, shoulders, and head) and rest or try to go back to sleep.