Tricyclic Antidepressants

Tricyclic antidepressants help to preserve catecholamines* in the brain. They include amitriptyline (Elavil®), protriptyline (Vivactil®), nortriptyline (Pamelor®), imipramine (Tofranil®), desipramine (Norpramin® and Pertofrane®), and doxepin (Sinequan®). These medications are often used in patients who experience frequent, daily or near-daily headaches. Continue Reading

Amitriptyline – Elavil

Amitriptyline is included in a group of medications classified as tricyclic antidepressants. Amitriptyline is one of the first successful medications in this class to be developed. It was discovered in the late 1930s before scientists had today’s understanding of the chemistry of the brain. This drug was developed as a way to reduce anxiety. Frequently, people with depression are often very anxious. When amitriptyline was given to patients with anxiety, it also improved the depression. This result prompted further research and the development of newer agents to treat depression. As scientific understanding of the brain progressed, scientists discovered that amitriptyline and related compounds worked on a series of chemicals called neurotransmitters. The antidepressants influenced the production and efficiency of these neurotransmitters. Continue Reading