Lasmiditan Passes Phase II Study

Another entry in the race to develop a new generation of migraine treatments is showing promise. Lasmiditan (also known as COL-144) was found to be effective for acute migraine attacks in a Phase IIb study. CoLucid Pharmaceuticals, Inc. describes the drug as “a first-in-class Neurally Acting Anti-Migraine Agent (NAAMA) designed to deliver efficacy in migraine without the vasoconstrictor activity associated with previous generations of migraine therapy. COL-144 selectively targets 5HT1F receptors expressed in the trigeminal nerve pathway.” Continue Reading


Indocin® – Indomethacin

Indomethacin (Indocin®) is an analgesic. It is classified as a nonsteroidal anti-inflammatory drug. These are commonly referred to as NSAIDS. Other NSAIDS are also used as analgesics. Indomethacin can be used as a pain reliever or analgesic. It can also be used as a treatment for arthritis, fever or other conditions where inflammation plays a role in creating the symptoms. Continue Reading


Ibuprofen

1024px-Equate_Ibuprofen_Pills_and_Bottle

Ibuprofen is an analgesic. It is classified as a nonsteroidal anti-inflammatory drug, commonly referred to as NSAIDS. Other NSAIDS are also used as analgesics. Ibuprofen can be used as a pain reliever or analgesic. It can also be used as a treatment for arthritis, fever or other conditions where inflammation plays a role in creating the symptoms. Unlike steroids, the side effects with ibuprofen are not as likely to be common or severe. The most common side effects include stomach upset, dizziness and tiredness. It may make stomach ulcers worse or cause upper gastrointestinal bleeding. It can have effects on kidney and liver functioning when used chronically. The frequent use of NSAIDs can increase the risk of cardiovascular disease.

Studies with this agent have demonstrated it to be effective in tension-type headache. Other NSAIDS have been shown to be effective in migraine both for prevention of migraine as well as treating the acute migraine attack. Ibuprofen is available over the counter at a reduced dose from the prescription form of t
he medication. A variety of trade names are used including Advil®, Motrin® and Nuprin®.