How do they work?

   A Closer Look

   Antiepileptic Medications

   AEDs Used in Migraine
   Prevention


   Other Preventive Medications
   at a Glance

   Controlling the Pain
   without Medication


   Developing an Effective
   Treatment Plan


AEDs Commonly Used in Migraine Prevention

Drug name
(Brand name)

Recommended Usage*

Side Effects
& Notes

FDA-Approved
for migraine?

Topiramate (Topamax)

Two times a day, depending on dose

May cause fatigue, dizziness, or confusion8

Some patients may experience weight loss5

Yes

Divalproex Sodium (Depakote)

Two to four times a day, depending on dose

May cause weight gain and hair loss5

Yes

Divalproex Sodium (Depakote ER)

Once a day

Well-tolerated

Fewer side effects than delayed-release tablets8

Yes

Lamotrigine (Lamictal)

Once a day

Not effective in migraine w/aura

May cause rash5

No

Gabepentin (Neurontin)

Three times a day or greater, depending on dose

Well-tolerated

Can cause drowsiness5

No

Carbamazepine (Tegretol)


Two to three times a day, depending on dose

May cause drowsiness6

May cause rash

No

Phenytoin (Dilantin)

Once a day, depending on dose and formulation

May cause drowsiness or dizziness6

No

* Recommended dosages are listed based on a review of current literature and are intended only as a general guide. As always, consult with your healthcare professional to determine usage that is appropriate for you.

5. Mannix L. Prophylactic treatment of migraine. Presented at Diamond Headache Clinic Research and Education Foundation. Orlando, FL; July 2000.

6. Hansen HC. Treatment of chronic pain with antiepileptic drugs: a new era. South Med J. 1999;92(7):642-649.

8. DEPAKOTE ERŪ [package insert]. Chicago, IL: Abbott Laboratories;2000.