Antiepileptic Medications

During the past few years, there has been an increased interest in antiepileptic drugs (AEDs, sometimes referred to as "anticonvulsants" or "antiseizure" medications) for the prevention of migraine. After all, both epilepsy and migraine may be caused by similar reactions in the brain.

As the Table AEDs Commonly Used in Migraine Prevention shows, there is plenty of scientific support for the effectiveness and safety of AEDs for migraine prevention. Currently, the only AEDs with FDA approval for migraine prevention are Depakote (divalproex sodium valproate) and Topamax (topiramate), the latter of which was recently approved after two clinical trials showed it could significantly reduce the frequency of migraine attacks without causing serious side effects.

As with other drugs used for preventing migraine attacks, the side effects associated with AEDs may play an important role in a physician’s final drug selection. Some patients, for example, experience weight gain as a result of taking an AED to prevent migraine attacks. For these patients, the doctor may suggest another AED, such as Topamax or Neurontin, that has not been associated with weight gain. Similarly, for patients who experience drowsiness from taking Neurontin for migraine prevention, Depakote or Topamax (which are not associated with drowsiness) might be prescribed.

Each person is unique and responds to medication differently. But if migraine prevention medication is right for you, a qualified medical professional will help you figure out which treatment option best meets your needs.