Precipitating Factors

Unlike migraine headaches, cluster headaches are not the result of heredity. Sufferers, however, usually do have a history of chronic smoking, and alcohol frequently triggers a cluster headache.

Because the level of histamine increases in a person's blood and urine during a cluster headache, many researchers believe that histamines, which dilate or expand blood vessels, influence a cluster headache. Antihistamines have not proven, however, to be effective therapy.

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