Enkephalins/Endorphins

These two groups of compounds comprise the basis for the body's own pain fighting mechanisms. The enkephalins are found in many areas of the body, and the endorphins are primarily located within the brain itself. Changes in these compounds and their metabolism have been associated with different headache disorders. Their exact role has not been determined. These compounds could play a role in the cause of headache itself. Some headache therapies may act by working on these chemicals.

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