Researchers looking to evaluate the existing evidence on the effectiveness of magnesium for migraine found that the mineral may be effective. The results of their analysis were published in Headache.
A comprehensive search of studies from 1990 to 2016 found 5 clinical trials that addressed a double-blind, randomized, placebo-controlled trial investigating the effect of magnesium on migraine in adults. Researchers focused on the number of migraine attacks, as well as the reduction of migraine days.
The clinical trials used for this analysis covered menstrual migraine, migraine with and without aura, as well as standard migraine symptoms. One of the two Class I evidence trials—which are considered to be the most reliable trials for effective treatment—found magnesium can significantly reduce the number of migraine attacks compared to placebo.
Of the three Class III trials, a lower standard of evidence, two showed a significantly reduced number of migraine attacks and migraine days compared to placebo.
Based on these findings, researchers found grade C evidence (possibly effective) for prevention of migraine with magnesium. They suggest high levels of magnesium (600 mg) to be a safe and cost efficient strategy.
The use of magnesium, however, should be avoided in certain instances, such as when diseases besides migraine are present. Because of this, it should be discussed with your healthcare professional.